Disclosed is the use of N4-(4-([1,2,4]triazolo[1,5-alpha]pyridin-7-yloxy)-3-methylphenyl)-N6-(4,4-dimethyl-4,5-dihydrooxazol-2-yl)quinazoline-4,6-diamine or (2-((4-((4-([1,2,4]triazolo[1,5-a]pyridin-7-yloxy)-3-methylphenyl)amino)quinazolin-6-yl)amino)-4-methyl-4,5-dihydrooxazol-4-yl)methanol in the manufacture of a medicament for the treatment of local or metastatic brain cancer that is caused by ErbB2 over-expression or amplification, wherein the N4-(4-([1,2,4]triazolo[1,5-alpha]pyridin-7-yloxy)-3-methylphenyl)-N6-(4,4-dimethyl-4,5-dihydrooxazol-2-yl)quinazoline-4,6-diamine or (2-((4-((4-([1,2,4]triazolo[1,5-a]pyridin-7-yloxy)-3-methylphenyl)amino)quinazolin-6-yl)amino)-4-methyl-4,5-dihydrooxazol-4-yl)methanol is in the form of a tablet. Further disclosed is the combination of said medicament with trastuzumab, capecitabine, bevacizumab, paclitaxel or docetaxel.
