Kirill YAKOVLEVSKY;Michael Shamashkin;Chu W. Jung;Nazer Khalaf;Chandrika P. Govardhan
发明人:
Kirill YAKOVLEVSKY,Michael Shamashkin,Nazer Khalaf,Chandrika P. Govardhan,Chu W. Jung
申请号：
US13192345
公开号：
US20120282464A1
申请日:
2011.07.27
申请国别(地区):
US
年份:
2012
代理人:
摘要：
This invention relates to SPPs, spherical nanocrystalline composite particles or crystalline SPPs of biologically active proteins or compositions, including formulations, comprising such SPPs, spherical nanocrystalline composite particles or crystalline SPPs. More particularly, methods are provided for the production of SPPs, spherical nanocrystalline composite particles or crystalline SPPs of high concentrations of biologically active proteins, and for the preparation of stabilized SPPs, spherical nanocrystalline composite particles or crystalline SPPs for use alone, or in dry or slurry compositions. This invention also relates to methods for stabilization, storage and delivery of biologically active proteins using SPPs, spherical nanocrystalline composite particles or crystalline SPPs. The present invention further relates to methods using SPPs, spherical nanocrystalline composite particles or crystalline SPPs, or compositions or formulations comprising such SPPs, spherical nanocrystalline composite particles or crystalline SPPs, for biomedical applications, including biological delivery to humans and animals.
