Disclosed is use of alphavirus in preparation of antitumor drugs. The alphavirus is M1 virus or Getah virus. In addition, the specific tumor types sensitive to the abovementioned alphavirus treatment are further determined, so as to provide a safe and effective solution for antitumor drug administering schemes.本發明屬於生物醫藥領域,涉及甲病毒用於製備抗腫瘤之醫藥組合物的用途,其中所述的甲病毒為M1病毒或蓋塔病毒。本發明進一步地確定了對上述甲病毒治療敏感的特定腫瘤類型,從而為抗腫瘤用藥方案提供了更為安全有效的解決方案。