KSANDER, GARY MICHAEL,MEREDITH, ERIK,MONOVICH, LAUREN G.,PAPILLON, JULIEN,FIROOZNIA, FARIBORZ,HU, QI-YING
申请号：
CA2619660
公开号：
CA2619660C
申请日:
2006.08.23
申请国别(地区):
CA
年份:
2015
代理人:
摘要：
The present invention provides a compound of formula (I): Said compoundis inhibitor of aldosterone synthase and aromatase, and thus can be employedforthe treatment of a disorder or disease mediated by aldosterone synthase oraromatase.Accordingly, the compound of formula I can be used in treatment ofhypokalemia,hypertension, congestive heart failure, atrial fibrillation, renal failure, inparticular,chronic renal failure, restenosis, atherosclerosis, syndrome X, obesity,nephropathy,post-myocardial infarction, coronary heart diseases, inflammation, increasedformationof collagen, fibrosis such as cardiac or myocardiac fibrosis and remodelingfollowinghypertension and endothelial dysfunction, gynecomastia, osteoporosis, prostatecancer, endometriosis, uterine fibroids, dysfunctional uterine bleeding,endometrialhyperplasia, polycystic ovarian disease, infertility, fibrocystic breastdisease, breastcancer and fibrocystic mastopathy. Finally, the present invention alsoprovides a pharmaceuticalcomposition.
