This invention relates to isolated polypeptides that are glucagon-receptor selective analogs and peptide derivatives thereof. These analogs are selective for human glucagon receptor with improved solubility, thermal stability, and physicochemical properties as compared to native endogenous glucagon. This invention also relates to methods of using such polypeptides in a variety of therapeutic and diagnostic indications, as well as methods of producing such polypeptides. These analogs are useful, alone or in combination with other therapeutic peptides, in methods of treating obesity, diabetes, metabolic disorders, and other disorders or disease.本發明關於單離多肽類，該等單離多肽係升糖素受體選擇性類似物及其肽衍生物。這些類似物對人類升糖素受體具有選擇性且相較於天然內源性升糖素具有改善的溶解度、熱穩定性及物理化學性質。本發明亦關於使用該等多肽於各種治療性及診斷性適應症之方法以及生產該等多肽之方法。這些類似物可單獨或與其他治療肽組合以用於治療肥胖、糖尿病、代謝性病症及其他病症或疾病之方法。
