CTLA4 mutant molecule or nucleic acid molecule, vector and host vector system, host cell, CTLA4 mutant protein, method for producing and use thereof, pharmaceutical composition and regulation method
PEACH ROBERT J.,NAEMURA JOSEPH R.,LINSLEY PETER S.,BAJORATH JURGEN
申请号：
SK15702002
公开号：
SK288131B6
申请日:
2001.05.23
申请国别(地区):
SK
年份:
2013
代理人:
摘要：
Disclosed are a CTLA4 mutant molecule, a nucleic acid molecule which comprises a nucleotide sequence encoding an amino acid sequence corresponding to the CTLA4 mutant molecule, a vector comprising the nucleic acid sequence, a host vector system comprising said vector, a host cell having said vector, a method for producing a CTLA4 mutant protein, the CTLA4 mutant protein obtained by said method, a pharmaceutical composition comprising the CTLA4 mutant molecule, an in vitro method for regulating a T cell interaction with a CD80 and/or CD86 positive cell, as well as a use of CTLA4 mutant molecule for preparing a pharmaceutical composition for treating an immune system disease.Disclosed are a CTLA4 mutant molecule, a nucleic acid molecule which comprises a nucleotide sequence encoding an amino acid sequence corresponding to the CTLA4 mutant molecule, a vector comprising the nucleic acid sequence, a host vector system comprising said vector, a host cell having said vector, a method for producing a CTLA4 mutant protein, the CTLA4 mutant protein obtained by said method, a pharmaceutical composition comprising the CTLA4 mutant molecule, an in vitro method for regulating a T cell interaction with a CD80 and/or CD86 positive cell, as well as a use of CTLA4 mutant molecule for preparing a pharmaceutical composition for treating an immune system disease.
