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НОВАЯ КОМБИНАЦИЯ
专利权人:
Новартис Тиргезундхайт АГ (CH)
发明人:
ГРМАС Ерней (SI),ЕРАЛА-СТРУКЕЛЬ Зденка (SI),РЕВЕН Себастьян (SI)
申请号:
RU2014129508
公开号:
RU2014129508A
申请日:
2012.12.19
申请国别(地区):
RU
年份:
2016
代理人:
摘要:
1. A combination comprising a fixed dose benazepril hydrochloride and pimobendan in the form of a bilayer tabletki.2. Combination according to Claim. 1, stable over 36 months at 25 ° C.3. Combination according to Claim. 1 or 2, comprising 5 mg and 10 mg pimobendan benazeprila.4 hydrochloride. Combination according to Claim. 1 or 2, comprising 1.25 mg and 2.5 mg pimobendan benazeprila.5 hydrochloride. Combination according to Claim. 1 or 2 wherein the benazepril layer contains the active ingredient in the form of benazepril hydrochloride benazeprila.6 microspheres. Combination according to Claim. 1 or 2, wherein pimobendan layer is in the form of granular sostava.7. Combination according to Claim. 1 or 2, for use in treating congestive heart failure in sobak.8. Use of a combination according to any one of claims. 1-7 for the preparation of a medicament for the treatment of congestive heart failure in sobak.9. A process for preparing a combination gdea) a granular composition pimobendan, b) is prepared microspheres benazepril, c) microspheres benazepril obtained in b), further mixed with excipients to form a mixture, and d) the granular formulation and the mixture obtained in a) and c), jointly compressed to form a bilayer tabletki.10. A method of treating congestive heart failure in a dog comprising administering a combination according to any one of claims. 1-6.11. The method of claim. 10 wherein the combination is administered twice a sutki.12. The method of claim. 10 or 11 wherein the release characteristics of benazepril hydrochloride and pimobendan equivalent combination of release characteristics of benazepril hydrochloride and pimobendan when administered as single agents.1. Комбинация, содержащая фиксированные дозы гидрохлорида беназеприла и пимобендана в форме двуслойной таблетки.2. Комбинация по п. 1, стабильная более 36 месяцев при 25°С.3. Комбинация по п. 1 или 2, содержащая 5 мг пимобендана и 10 мг гидрохлорида беназеприла.4. Комбинация по п. 1 или 2, со
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