The present invention relates to a vaccine against porcine drcovirus type 2(PCV-)2 and a method for the manufacture of such a vaccine, for protectingpiglets against PCV-2 infection. It has been found that a vaccine comprisingat least 20 microgram/dose of ORF-2 protein of porcine circovirus type 2 (PCV-2 is capable of eliciting a protective immune response against PCV-2 (and thusagainst PMWS) even when they have a relatively high titer of MDA against PCV-2. A vaccine according to the invention may contain a recombinant ORF-2protein, wherein said recombinant protein is preferably produced by way ofexpression from a baculovirus expression vector in insect cells, saidbaculovirus expression vector containing the PCV-2 ORF-2 gene sequence undercontrol of a suitable promoter.
