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液體冷卻滴丸的連續智慧製備方法
专利权人:
TASLY PHARMACEUTICAL GROUP CO.; LTD.
发明人:
YAN, KAIJING,闫凯境,閆凱境,SUN, XIAOBING,孙小兵,孫小兵,RONG, CHANGSHENG,荣昌盛,榮昌盛,CAI, XUEFEI,蔡雪飞,蔡雪飛,WANG, LIANG,王亮
申请号:
TW105129960
公开号:
TW201717887A
申请日:
2016.09.14
申请国别(地区):
TW
年份:
2017
代理人:
摘要:
An intelligent continuous manufacturing method via liquid cooling of dripping pills comprises the following steps: (1) feeding: weighing and transferring multiple materials respectively; (2) material combining: performing staged heating on the materials transferred in step (1), and mixing the same to obtain a material mixture, wherein an RSD of an effective ingredient in the material mixture ≤ 5%; (3) homogenizing: pressurizing the material mixture obtained in step (2), and increasing the temperature, so as to obtain a homogenized material having the RSD of the effective ingredient in the material mixture ≤ 5%; (4) dripping: performing vibration dripping on the homogenized material obtained in step (3) to obtain dripping pills, delivering the dripping pills into a cooling liquid to be cooled and then transferred; and (5) de-oiling: removing the cooling liquid on surfaces of the dripping pills obtained in step (4) via tilting centrifugation. The manufacturing method not only shortens the manufacturing process, but also ensures the dripping pill product to be more stable and homogeneous. In addition, high-speed centrifugation is used to reasonably de-oil the dripping pills to prevent contamination of the dripping pills and improve the circulation utilization rate of the cooling liquid.本發明提供一種液體冷卻滴丸的連續智慧製備方法,包括如下步驟:步驟1)餵料,將多種物料分別稱重、輸送;步驟2)混料,對步驟1)輸送的物料藉由分級加熱、混合,得到混合物料,混合物料中有效成分RSD≦5%;步驟3)均質,對步驟2)得到的混合物料進行加壓、升溫,得到有效成分RSD≦5%的均質物料;步驟4)滴製,將步驟3)得到的均質物料進行振動滴製後,得到滴丸,滴丸投入冷卻液進行冷卻後輸送;以及步驟5)脫油,藉由傾斜離心方式脫除步驟4)輸送的滴丸表面的冷卻液。本發明不僅縮短整個製備過程經過的時間,確保滴丸產品更具穩定性和均勻性,且藉由採用高速離心的方式合理對滴丸脫油,即防止滴丸被污染,又提高冷卻液的迴圈利用率。
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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