V. BETAGERI, GURU V.,贝塔杰利 古鲁,貝塔傑利 古魯,VENKATESAN, NATARAJAN,文卡特森 纳塔拉杰,文卡特森 納塔拉傑,G. OEFELEIN, MICHAEL G.,欧费莱恩 麦可,歐費萊恩 麥可
申请号：
TW106123033
公开号：
TW201817416A
申请日:
2017.07.10
申请国别(地区):
TW
年份:
2018
代理人:
摘要：
Compositions and methods for making and using proliposomal and liposomal formulations of chemotherapeutic agents are disclosed. The proliposomal and liposomal formulations of chemotherapeutics, as well as medicaments and dosage forms that include such formulations, can be used with treatment regimens for bladder cancer and urothelial cancer. Hence, the formulations, medicaments, and dosage forms of the invention are suitable to treat bladder cancers by intravesical administration and to treat urothelial cancers. The formulations according to the invention include (a) a taxane (e.g., paclitaxel, docetaxel) or cisplatin, (b) a first phospholipid, 1,2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC), and (c) a second phospholipid, dimyrsityl phosphatidyl glycerol sodium (DMPG). The proliposomal formulations form liposomes upon contact with an aqueous vehicle.係揭示一種用於製造與使用化療用前體脂質體與脂質體配方之組成物與方法。該化療用前體脂質體與脂質體配方,以及包括此配方之藥物與藥劑形式,可與膀胱癌和尿道上皮癌的治療處方一同使用。因此,本發明之配方、藥物與藥劑形式,適用於經由膀胱內投藥治療膀胱癌,以及治療尿道上皮癌。本發明配方包括(a)紫杉烷(如紫杉醇、多西紫杉醇(docetaxel))或順鉑、(b)第一磷脂質,即1,2-二肉豆蔻醯基-sn-甘油基-3-磷酸膽鹼 (DMPC),以及(c)第二磷脂質,即二肉豆蔻醯基磷脂醯基甘油鈉(DMPG)。該前體脂質體配方會在與水性載劑接觸時形成脂質體。(無)
