CELLULES TUEUSES NATURELLES (NK) GROUPÉES ISSUES DU SANG DE CORDON OMBILICAL ASSOCIÉES À DES ANTICORPS ET LEURS UTILISATIONS POUR LE TRAITEMENT D'UNE MALADIE
The invention relates to the field of cell therapy, particularly NK cell mediated therapy associated with antibodies. The present invention is directed to methods and compositions for increasing the efficiency of therapeutic natural killer cells (NK cells) and/or antibodies, wherein said methods or compositions comprise the use of pooled NK cells from umbilical cord blood units (UCBs), preferably alloreactive NK cells, in combination with a therapeutic antibody in order to enhance the efficiency of the treatment in human subjects, in particularly through an increase in antibody-dependent cell-mediated cytotoxicity (ADCC) mechanism. The present invention relates to said composition as a pharmaceutical composition, preferably for its use for the treatment of a disease in a human subject in need thereof, preferably wherein said disease is a cancer, infectious or immune disease. Finally, the present invention is also directed to a method of treatment of a disease in a human subject in need thereof, comprising the administering to said subject said pooled NK cells from UCBs, preferably alloreactive, in combination with a therapeutic antibody which can be bound to said NK cells.L'invention concerne le domaine de la thérapie cellulaire, en particulier de la thérapie médiée par les cellules NK associées à des anticorps. La présente invention concerne des procédés et des compositions permettant d'augmenter l'efficacité des cellules tueuses naturelles (cellules NK) et/ou des anticorps hérapeutiques, lesdits procédés et compositions comprenant l'utilisation de cellules NK regroupées à partir d'unités de sang de cordon ombilical (unintés UCB), de préférence des cellules NK alloréactives, en association avec un anticorps thérapeutique afin d'augmenter l'efficacité du traitement chez des sujets humains, en particulier par une augmentation du mécanisme de cytotoxicité à médiation cellulaire dépendante d'anticorps (ADCC). La présente invention concerne ladite composition en tant qu
