An anchor trajectory guide and methods of use thereof are provided. The guide includes a body that has a medial side. The medial side can be placed over a lateral side of a fixation plate. The anchor trajectory guide also includes a locator and a plurality of guide apertures. The locator is disposed on or through the medial side of the body. The locator can be mated with the fixation plate. The guide apertures are disposed through the body at positions corresponding to define anchor locations and orientations to provide good purchase adjacent to or in cortical bone around a medial side of a humerus.