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LIBRARIES OF OPTIONS OF IMMUNOLOGICAL SYNAPSIS AND THEIR SYNTHESIS
专利权人:
ТВИСТ БАЙОСАЙЕНС КОРПОРЕЙШН
发明人:
Кокс, Энтони,Чэнь, Сыюань,Энтони,Сыюань
申请号:
EA201991262
公开号:
EA201991262A1
申请日:
2017.12.15
申请国别(地区):
EA
年份:
2020
代理人:
摘要:
Disclosed herein are methods for the generation of highly accurate nucleic acid libraries encoding for predetermined variants of a nucleic acid sequence. The nucleic acid sequence may encode for all or part of a TCR or a TCR-binding antigen. The degree of variation may be complete, resulting in a saturated variant library, or less than complete, resulting in a non-saturating library of variants. The variant nucleic acid libraries described herein may designed for further processing by transcription or translation. The variant nucleic acid libraries described herein may be designed to generate variant RNA, DNA and/or protein populations. Further provided herein are method for identifying variant species with increased or decreased activities, with applications in regulating biological functions and the design of therapeutics for treatment or reduction of a disease, such as cancer.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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