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DI(HETERO)ARYLCYCLOHEXANE DERIVATIVES, THEIR PREPARATION, THEIR USE AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM
专利权人:
SANOFI
发明人:
JEAN-MICHEL ALTENBURGER,HEINZ-WERNER KLEEMANN,THOMAS BÖHME,UWE GERLACH,DIRK GRETZKE,STEFANIA PFEIFFER-MAREK,JEAN-MICHEL ALTENBURGER,HENNING VOLLERT,SERGIO MALLART
申请号:
PT08758710
公开号:
PT2164825E
申请日:
2008.05.23
申请国别(地区):
PT
年份:
2014
代理人:
摘要:
The present invention relates to di(hetero)arylcyclohexane derivatives of the formula I, in which Ar1, Ar2, R1 and R2 have the meanings indicated in the claims. The compounds of the formula I are valuable pharmaceutical active compounds which inhibit ATP-sensitive potassium channels in the heart muscle and are suitable, for example, for the treatment of disorders of the cardiovascular system such as arrhythmias or a decreased contractility of the heart, such as can occur, for example, in coronary heart disease, cardiac insufficiency or cardiomyopathies. In particular, they are suitable for the prevention of sudden cardiac death. The invention furthermore relates to processes and intermediates for the preparation of the compounds of the formula I, their use and pharmaceutical compositions comprising them.
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中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/
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