GOSSELIN GILLES,IMBACH JEAN-LOUIS,BRYANT MARTIN L.
申请号：
IN3149/DELNP/2007
公开号：
IN254551B
申请日:
2007.04.26
申请国别(地区):
IN
年份:
2012
代理人:
摘要：
This invention is directed to a method for treating a host infected with hepatitis B comprising administering an effective amount of an anti-HBV biologically active 2-deoxy-ß-L-erythro-pentofuranonucleoside or a pharmaceutically acceptable salt or prodrug thereof, wherein the 2-deoxy-p-L-erythro-pentofuranonucleoside has formula (I) wherein R is selected from the group consisting of H, straight chained, branched or cyclic alkyl, CO-alkyl, CO-aryl, CO-alkoxyalkyl, CO-aryloxyalkyl, CO-substituted aryl, alkylsulfonyl, arylsulfonyl, aralkylsulfonyl, amino acid residue, mono, di, or triphosphate, or a phosphate derivative and BASE is a purine or pyrimidine base which may be optionally substituted. The 2-deoxy-ß-L-erythro-pentofuranonucleoside or a pharmaceutically acceptable salt or prodrug thereof may be administered either alone or in combination with another 2-deoxy-ß-L-erythro-pentofuranonucleoside or in combination with another anti-hepatitis B agent.
