<;P>;PROBLEM TO BE SOLVED: To provide a new plasminogen activator which prevents thrombosis or rethrombosis by limitedly decomposing fibrinogen. <;P>;SOLUTION: This plasminogen activator contains cells of lactic acid bacteria as an active ingredient, wherein the lactic acid bacteria are desirably at least one selected from among Lactococcus lactis ssp. lactis, Lactococcus lactis ssp. lactisbv. diacetylactis, and Lactobacillus bulgaricus, and further it is desirable that the cells of the lactic acid bacteria are heat-treated at a temperature of 80-150°;C for 5-40 min. Further, the plasminogen activator can utilize a product obtained by extracting the cells of the lactic acid bacteria with an extractant of a pH of 7-14. <;P>;COPYRIGHT: (C)2010,JPO&INPIT