SHAH LIPA,샤, 리파,SUTTON PAUL ALLEN,서턴, 폴 알렌,ZHANG LIJUN,장, 리준
申请号：
KR1020137011801
公开号：
KR1020140000689A
申请日:
2011.10.08
申请国别(地区):
KR
年份:
2014
代理人:
摘要：
The invention provides new salts and polymorphs of (5R,8S)-7-[(2S)-2-{[(2S)-2-cyclohexyl-2-({[(2S)-1-isopropylpiperidin-2-yl]carbonyl}amino)acetyl]amino}-3,3-dimethyl butanoyl]-N-{(1R,2R)-2-ethyl-1-[(pyrrolidin-1-ylsulfonyl)carbamoyl]cyclopropyl}-10,10-dimethyl-7-azadispiro[3.0.4.1]decane-8-carboxamide (referred to herein as Compound X), pharmaceutical compositions containing them and processes for their manufacture and use in therapy.본 발명은 (5R,8S)-7-[(2S)-2-{[(2S)-2-시클로헥실-2-({[(2S)-1-이소프로필피페리딘-2-일]카르보닐}아미노)아세틸]아미노}-3,3-디메틸부타노일]-N-{(1R,2R)-2-에틸-1-[(피롤리딘-1-일술포닐)카르바모일]시클로프로필}-10,10-디메틸-7-아자디스피로[3.0.4.1]데칸-8-카르복스아미드 (본원에서 화합물 X로 지칭됨)의 신규 염 및 다형체, 그를 함유하는 제약 조성물, 및 그의 제조 방법, 및 요법에서의 용도를 제공한다.
