Methods and processes for preparation and production of deuterated .omega.-diphenylureaare disclosed. Especially, a kind of deuterated .omega.-diphenylurea compoundswhich can inhibit phosphokinase and the preparation method of N-(4-chloro-3-(trifluoromethyl)phenyl)-N'-(4-(2-(N-d3-methylcarbamoyl)-4-pyridinyloxy)phenyl)ureaare disclosed. The said deuterated diphenylurea compounds can be used fortreating orpreventing tumors and relative diseases.(see above formula)