Huaizhong Pan;Jindrich Kopecek;Pavla Kopecková;Kui Luo;Jiyuan Yang
发明人:
Pavla Kopecková,Huaizhong Pan,Jiyuan Yang,Jindrich Kopecek,Kui Luo
申请号：
US13583270
公开号：
US20130156722A1
申请日:
2011.03.07
申请国别(地区):
US
年份:
2013
代理人:
摘要：
Described herein are biodegradable drug delivery conjugates for effectively delivering bioactive agents to a subject. The drug delivery conjugates comprise a water-soluble high molecular weight linear biodegradable polymer backbone comprising a plurality of linear water-soluble polymeric segments connected to one another by a first (main-chain) cleavable linker, wherein a bioactive agent is covalently bonded to at least one water-soluble polymeric segment, at least one cleavable linker, or a combination thereof. The conjugates possess numerous advantages over prior art delivery conjugates. Also described herein are methods for making and using the conjugates.
