Ariel Fernandez,William Bornmann,Gabriel Lopez-Berestein,Angela Sanguino,Zheng-Hong Peng,Anil K. Sood
申请号：
US11927329
公开号：
US20130131076A1
申请日:
2007.10.29
申请国别(地区):
US
年份:
2013
代理人:
摘要：
This application describes a novel technology in drug discovery and drug-based imaging/detection: the wrapping technology. This technology is based on identified singularities in the structure of soluble proteins. In contrast with drug-design approaches based on standard structural considerations, the packing of a protein, or more precisely, its dehydron pattern, may be used as a selectivity filter to design small-molecule inhibitors. The wrapping technology described herein is a novel form of rational drug design for avoiding side effects in drug therapy and sharpening the inhibitory impact of drugs on the oncokinome.
