C. Shad Thaxton,Marina G. Damiano,Heng Zhang,Kaylin M. McMahon,Shuo Yang,Leo I. Gordon,Amareshwar T.K. Singh
申请号：
US14380406
公开号：
US20150064255A1
申请日:
2013.02.22
申请国别(地区):
US
年份:
2015
代理人:
摘要：
Nanostructures, compositions and methods for treating cancers and other conditions are provided. In some cases, the nanostructures and/or compositions may be used to treat cancers or other diseases or conditions at least in part by controlling cholesterol metabolism in cells. The nanostructures and compositions may be used, for example, to control cholesterol influx and/or efflux in cells. In some cases, the nanostructures or compositions may be used to kill the cells. Examples of cancer cells that may be affected by the nanostructures and compositions described herein include those having scavenger receptor type B-I (SR-B1), B-cell lymphoma cells, non-Hodgkin's lymphoma cells, melanoma cells and/or others. In some embodiments, the nanostructures may be mimics of natural high-density lipoprotein (HDL).
