A system for attaching an access port to bodily tissue includes an access port assembly and including an access port having a generally central axis (52). The access port assembly further includes an attachment mechanism structured to enable the access port to be attached, for example, to an abdominal muscle of a patient. The system includes a rotating activator (62) having first and second protrusions (112) receiving an anchor (70) therebetween for reversibly deploying the anchor in a camming manner.