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PDE 9 pyridine inhibitor
专利权人:
MERCK SHARP & DOHME CORP.
发明人:
申请号:
ARP180101518
公开号:
AR112073A1
申请日:
2018.06.06
申请国别(地区):
AR
年份:
2019
代理人:
摘要:
9. Pyridine compounds that can be used as therapeutic agents for phosphate-9 (pde-9) disorders. It also refers to the use of these compounds in the treatment of neurological and psychiatric disorders, such as schizophrenia, psychosis or Huntington's disease, as well as diseases related to low or dysfunctional females in the basal nucleus. 1. Characteristic requirement 1: a compound of formula [1], wherein: A is a cyclomethane compound, which is not replaced or replaced by an alternative selected from fluorination and methyl; R1,R 2 and R 3 were selected independently: (1) hydrogen, (2) halogen, (3) hydroxy, (4) c83331832626 tar;a. It is not replaced or replaced by the alternative selected from the following items: hydrogen Xi and fluorination, (5) - O-alkyl c833218331832626;(6) C83323318326 was not replaced or replaced with the selected fluorinated substitute;Y (7) - CN; r83088 was selected from: (1) hydrogen (2) - ch83323;(3)CF8323,(4) - ch8322; (5) - co8322; (H) and (6) - ch8322; (ch832323);R83099 is a ring of phenyl, pyridine, pyridyl, pyridyl or pyridyl, in which the ring of phenyl, pyridine, pyridyl or pyridyl is replaced by r749191;R1.74959 and r1.758080,At R74919,R1.74959 and r1.758080 were selected from: (1) hydrogen, (2) halogen, (3) hydroxy, (4) c833218331ique 832626;a. It is not replaced or replaced by the alternative selected from the following items: hydrogen Xi and fluorination, (5) - O-alkyl c833218331832626;(6) C83323318326 was not replaced or replaced with the selected fluorinated substitute;If you are already registered, please log in first.Compuestos de pirazolopirimidina que pueden ser útiles como agentes terapéuticos para el tratamiento de trastornos asociados con la fosfodiesterasa 9 (PDE9). También se refiere al uso de dichos compuestos para tratar trastornos neurológicos y psiquiátricos, tales como esquizofrenia, psicosis o enfermedad de Huntington, y los asociados con hipofunción estriatal o disfunción de los núcleos basales. Reivindicación
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