POLYMORPHE ANHYDRE A1 DE [(2R, 3S, 4R, 5R)-5-(6-(CYCLOPENTYLAMINO)-9H-PURIN-9-YL) -3,4-DIHYDROXYTETRAHYDROFURAN-2-YL)] MÉTHYL NITRATE ET SES PROCÉDÉS DE PRÉPARATION
The present invention provides a novel anhydrous polymorph form of [(2R,3S,4R,5R) -5-(6-(cyc]opentylamino)-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)]methyl nitrate (Compound A). The present invention also provides processes for preparation of the anhydrous polymorphic form of compound A, compositions containing the polymorph form, and use of the polymorph form for the preparation of ophthalmic compositions.