Yuling Liu,Xuejun Xia,Ruifang Guo,Pengxiao Zhang,Rui Han,Zhaodi Fu,Cuiping Zhou,Renyun Wang,Dujia Jin
申请号：
US13505168
公开号：
US20120308616A1
申请日:
2010.10.28
申请国别(地区):
US
年份:
2012
代理人:
摘要：
A submicron emulsion of paclitaxel, the preparation method and the use thereof are disclosed. Said paclitaxel submicron emulsion comprises paclitaxel/steroid complex, oil for injection, water for injection, emulsifier, assistant emulsifier and isotonic agent, wherein the mole ratio of paclitaxel to steroid in the complex is 1:0.2˜4 preferably 1:0.25˜2. Said submicron emulsion is useful for the treatment for malignant tumor. The average particle diameter of the submicron emulsion is less than 400 nm and the pH Value is 3.5-6.
