As for this invention, at least, the wrinkle of the piperidine derivative of 1 where it is selected from the chemical compound, and its salt, and these optical isomers below-mentioned formula (i) kinds, the especially expression ji wa and fighting it is, at the same time/or eases the contraction of the skin, it regards beauty care use at the same time/or as a medicine in order to alleviate countenance. This invention, regards also the new piperidine derivative, and the cosmetics composition which contains these.本発明は、下記式(I)の化合物、およびその塩、ならびにこれらの光学異性体から選択される少なくとも1種のピペリジン誘導体の、シワ、特に表情じわと闘い、かつ/あるいは皮膚の収縮を緩和し、かつ/あるいは顔つきを和らげるための薬剤としての美容的使用に関する。本発明は、新規なピペリジン誘導体、およびこれらを含有する化粧品組成物にも関する。