ZHOU, HAN-JIE,SUN, CONGCONG M.,SHENK, KEVIN D.,LAIDIG, GUY J.
申请号:
CA2629084
公开号:
CA2629084C
申请日:
2006.11.09
申请国别(地区):
CA
年份:
2015
代理人:
摘要:
A compound having a structure of formula (I) or a pharmaceutically acceptablesalt thereof:(see formula I)whereinL is selected from C=O and C=S;X is selected from O, S, NH, and N-C1-6alkyl;Z is absent, C1-6alkyl, or C1-6alkoxy;R1, R2, and R3 are each independently selected from hydrogen, C1-6alkyl,C1-6alkynyl, C1-6hydroxyalkyl, C1-6alkoxyalkyl, aryl, C1-6aralkyl, heteroaryl,heterocyclyl,C1-6heterocycloalkyl, C1-6heteroaralkyl, carbocyclyl, and C1-6carbocycloalkyl;R4 is selected from hydrogen, C1-6aralkyl, and C1-6alkyl;R5 is heteroaryl; andR6 and R7 are independently selected from hydrogen, C1-6alkyl, and C1-6aralkyl.