PROBLEM TO BE SOLVED: To provide methods for treating systemic mast cell-related disorders such as irritable bowel syndrome, painful bladder syndrome or interstitial cystitis.SOLUTION: Disclosed herein is a method for administering to a patient a composition comprising a mast cell stabilizer such as cromolyn sodium, wherein the mast cell stabilizer has a bioavailability higher than about 5%, and the administration of the composition brings about an average AUC(0-∞) of the mast cell stabilizer greater than about 120 ng hr/mL and/or an average Cmax of the mast cell stabilizer greater than about 55 ng/mL. Preferably, the composition comprises one or more of purified water, sodium chloride, mannitol and sodium EDTA and is administered using a dry powder inhaler, metered dose inhaler, nebulizer or soft mist inhaler.SELECTED DRAWING: NoneCOPYRIGHT: (C)2019,JPO&INPIT【課題】敏性腸症候群、有痛性膀胱症候群又は間質性膀胱炎等の、全身性肥満細胞関連障害の治療のための方法の提供。【解決手段】クロモリンナトリウム等の肥満細胞安定剤を含む組成物を患者へ投与する方法であって、該肥満細胞安定剤のバイオアベイラビリティが約5%よりも大きく、かつ、該組成物の投与が、約120ng・hr/mLを上回る肥満細胞安定剤の平均AUC(0-∞)及び／又は約55ng/mLを上回る肥満細胞安定剤の平均Cmaxをもたらす方法。該組成物は、精製水、塩化ナトリウム、マンニトール、及びEDTAナトリウムのうちの1つ又は複数を含み、ドライパウダー吸入器、定量吸入器、ネブライザー、又はソフトミスト吸入器を用いて投与されることが好ましい。【選択図】なし
