GENERATION OF HUMAN PLURIPOTENT STEM CELL DERIVED FUNCTIONAL BETA CELLS SHOWING A GLUCOSE-DEPENDENT MITOCHONDRIAL RESPIRATION AND TWO-PHASE INSULIN SECRETION RESPONSE

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专利权人:

Janssen Biotech; Inc.

发明人:

Sebastian Rieck,Alireza Rezania

申请号：

US15622931

公开号：

US20170362572A1

申请日:

2017.06.14

申请国别(地区):

US

年份:

2017

代理人:

摘要：

The invention provides for methods of differentiating pancreatic endocrine cells into pancreatic beta cells expressing PDX1, NKX6.1, MAFA, UCN3 and SLC2A. These pancreatic beta cells may be obtained by step-wise differentiation of pluripotent stem cells. The pancreatic beta cells exhibit glucose-dependent mitochondrial respiration and glucose-stimulated insulin secretion similar to islet cells.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/