Trustees of Tufts College;Massachusetts Institute of Technology;Tufts Medical Center
发明人:
Michael House,David L. Kaplan,Errol Norwitz,Simona Socrate
申请号：
US14345758
公开号：
US20150064155A1
申请日:
2012.09.21
申请国别(地区):
US
年份:
2015
代理人:
摘要：
Methods, compositions, devices and kits for increasing mechanical stiffness of an incompetent or a dilated biological tissue in a subject are provided herein. The methods described herein involve placing (e.g., injecting) a silk fibroin-based composition into at least a portion of an incompetent or dilated tissue of a subject. In some embodiments, the silk fibroin-based composition can further comprise at least two PEG components that will crosslink together upon placement (e.g., injection) into a subject in need thereof. In specific embodiments, the methods, compositions, devices and kits can be used to increase mechanical stiffness of a cervical tissue in a subject, for example, for treatment of cervical insufficiency.
