The Board of Trustees of the Leland Stanford Junior University
发明人:
Jill Helms,Daniel J. Hunter
申请号：
US15539489
公开号：
US10512668B2
申请日:
2015.12.28
申请国别(地区):
US
年份:
2019
代理人:
摘要：
Methods and compositions are provided for enhancing dentin production, and for delivering a lipophilic agent to pulp tissue of a tooth of an individual. In some cases, a subject method includes a step of administering to the pulp of a tooth of an individual, a Wnt stimulating composition that includes a Wnt stimulator agent, at a dose sufficient to enhance the production of dentin by the pulp. In some cases, a subject method includes a step of contacting exposed dentin of a tooth with a composition that includes a lipophilic agent inserted in the non-aqueous phase of a lipid structure (e.g., whereby the lipophilic agent penetrates the dentin to the underlying pulp tissue). Kits are also provided for practicing the methods of the disclosure.
