The present invention discloses an anti-depression medicine or a health care food which utilizes the Jujuba cAMP as material, and its manufacturing method. A water extraction technique is used to extract Jujuba. The Jujuba extract can be made into different forms of medicine or health food, e.g. tablets, capsules, dispersions, powders, solutions, microencapsulations, suspensions, emulsions, granules, droplets, pellets, etc. According to the invention, the Jujuba extract can be added with flavors or other additives.本發明公開一種以大棗cAMP為原料製成的用於治療憂鬱症的藥物或保健食品及其製備方法。