The present invention relates to novel topical compositions and uses thereof which are useful in tissue local anaesthesia, in particular in the context of the prevention and/or treatment of pain and/or a premature ejaculation. The invention further provides a process of preparation of novel topical compositions and topical articles for anaesthesia such as wound dressing or bandage, sponge, gauze or condom coated or impregnated with a composition of the invention.