ЧЭНЬ Цзиньлин (US),НИАМВЕИА Нассер Н. (KE),ОНГ Кеннет К. Х. (CA)
申请号：
RU2013136384/15
公开号：
RU2013136384A
申请日:
2012.01.03
申请国别(地区):
RU
年份:
2015
代理人:
摘要：
1. A solid dosage form containing an API and at least one of croscarmellose or microcrystalline cellulose sodium, wherein the API is crystalline anhydrous (2S, 3R, 4R, 5S, 6R) -2- (4-chloro-3- (4- ethoxybenzyl) phenyl) -6- (methylthio) tetrahydro-2H-pyran-3,4,5-triol. 2. The solid dosage form according to claim 1, where the API is a crystalline anhydrous form 1 (2S, 3R, 4R, 5S, 6R) -2- (4-chloro-3- (4-ethoxybenzyl) phenyl) -6- (methylthio) tetrahydro -2H-pyran-3,4,5-triol. 3. The solid dosage form according to claim 1, where the API is a crystalline anhydrous form 2 (2S, 3R, 4R, 5S, 6R) -2- (4-chloro-3- (4-ethoxybenzyl) phenyl) -6- (methylthio) tetrahydro -2H-pyran-3,4,5-triol. 4. The solid dosage form according to claim 1, wherein the API is in an amount of 300 mg or less. The solid dosage form according to claim 1, which further comprises silicon dioxide. The solid dosage form according to claim 1, which is a tablet. A solid dosage form according to claims 1-6, which further comprises a second therapeutic agent, wherein the second therapeutic agent is an antidiabetic agent, an antihyperglycemic agent, a lipid-lowering / lipid-lowering agent, anti-obesity agents, an antihypertensive agent or an appetite-lowering agent. The solid dosage form according to claim 7, wherein the second therapeutic agent is a DPP-4 inhibitor (e.g., sitagliptin, dutogliptin). A granule containing an API and at least one of croscarmellose sodium, colloidal silicon dioxide and microcrystalline cellulose, where the API is (2S, 3R, 4R, 5S, 6R) -2- (4-chloro-3- (4-ethoxybenzyl) phenyl) -6- (methylthio) tetrahydro-2H-pyran-3,4,5-triol. 10. The granule according to claim 9, where the API represents crystalline anhydrous form 1 (2S, 3R, 4R, 5S, 6R) -2- (4-chloro-3-1. Твердая дозированная форма, содержащая API и по меньшей мере одно из натриевой соли кроскармеллозы или микрокристаллической целлюлозы, где API представляет кристаллический безводный (2S,3R,4R,5S,6R)-2-(4-хлор-3-(4-этоксибензил)фенил)
