The present invention relates to phenyl alkanoic acid derivatives (the compounds of Formula (I))； and their isotopic forms, stereoisomeric and tautomeric forms and mixtures thereof in all ratios,or pharmaceutically acceptable salts, pharmaceutically acceptable solvates, prodrugs, polymorphs, N-oxides, S-oxides or carboxylic acidisosteres thereof. The invention also relates to processes for the preparation of compounds of Formula (I) andpharmaceutical compositions comprising one or more of the compounds of Formula (I). The said compounds and the pharmaceutical composition function as GPR (G-protein coupled receptor) agonists, particularly as GPR40 agonists, and are useful in the treatment of diseases or conditions mediated by GPR40. The present invention further relates to a method of treatment of diseases or conditions mediated by GPR40comprising administering to a subject in need thereof a therapeuticallyeffective amount of the compounds of Formula (I).本發明係相關於苯基烷酸衍生物（結構式(I)之化合物）；以及其同位素形式、立體異構物以及互變異構物形式與其所有比率的混合物，或其藥學上可接受之鹽類、藥學上可接受之溶劑化物、前藥、多晶型物、N氧化物、S氧化物或羧酸同效物。本發明亦關於結構式(I)之化合物的製備程序，以及包含一或更多結構式(I)之化合物的藥學組成物。所述化合物與藥學組成物作為GPR（G蛋白耦合受體）促效劑，特別是GPR40促效劑，並且在經由GPR40媒介的疾病或症狀的治療是有用的。本發明進一步相關於經由GPR40媒介的疾病或症狀的治療方法，其包含投予對其有需要的受試者治療有效量的結構式(I)之化合物。
