PURPOSE: A nano-tagging particle for near infrared optical image is provided to check the in vivo optical image using a spectrum range of near infrared ray, and to have the excellent enrichment Raman scattering intensity, biocompatibility, and stability. CONSTITUTION: A nano-tagging particle for near infrared optical image comprises a silica core particle and a hollow metal nanoparticle layer surrounding the silica core particle. The average particle size of the silica core particle is 50-300 nm. The hollow metal nanoparticle is a hollow metal nanosphere. The hollow metal nanoparticle is a hollow gold nanoparticle, a hollow gold, and a silver nanoparticle. The surface of the hollow metal nanoparticle in the hollow metal nanoparticle layer is coated with a marker. A manufacturing method of the nano-tagging particle for near infrared optical image is as follows. The silica core particle is manufactured. The silver nanoparticle layer is formed on the surface of the silica core particle. The silica particle, in which the silver nanoparticle layer is formed, is reacted with gold ion so that the silica particle, in which the hollow gold and the silver nanoparticle layer are formed by Galvanic displacement reaction, is manufactured.본 발명은 실리카 중심 입자； 및 상기 실리카 중심 입자 주변을 둘러싸고 있는 할로우 금속 나노입자층；을 포함하여 이루어진 근적외선 광학영상용 나노-표지 입자, 그 제조방법 및 그를 이용한 생체 내 광학 검출방법에 관한 것으로, 본 발명은 근적외선 광학영상용 나노-표지 입자는 근적외선 영역의 파장을 이용하여 생체 내, 예를 들어 피하 조직의 광학영상을 확인할 수 있고, 표면증강 라만산란 강도가 뛰어나며, 생체적합성 및 안정성이 뛰어나므로, 생체 내 다중 광학영상을 얻기 위한 나노 프로브로서 활용될 수 있다.
