compound or a pharmaceutically acceptable salt thereof, pharmaceutical composition, xanthine oxidase inhibitor, and a therapeutic or prophylactic agent for a disease

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专利权人:

TEIJIN PHARMA LIMITED

发明人:

Akira Tanokura,Asahi Kawana,Chikashi Kanazawa,HIROYUKI TAKAHASHI,Mariko Imazeki,Masayuki Tera,Yoshimasa Takahashi

申请号：

BR112015024462

公开号：

BR112015024462A2

申请日:

2014.03.28

申请国别(地区):

BR

年份:

2017

代理人:

摘要：

1/1 summary “compound or a pharmaceutically acceptable salt thereof, pharmaceutical composition, xanthine oxidase inhibitor, and a therapeutic or prophylactic agent for a disease” are provided a compound expressed by Formula (i) or a pharmacologically permissible salt thereof, as well as a drug or drug composition containing this compound as an active ingredient, having a xanthine oxidase inhibiting effect which is very useful for treating or preventing disease. Conditions that are contributed by xanthine oxidase such as gout, hyperuricemia, tumor lysis syndrome, urinary tract calculi, hypertension, dyslipidemia, diabetes, cardiovascular disease such as heart failure and sclerosis artery, renal disease such as near diabetic opacity and the like, respiratory disease such as chronic obstructive pulmonary disease and the like, autoimmune diseases such as 1 §Receiving§ inflamatã³ria bowel and the like. [in the formula, a, x, y, z, r and r have the meanings set forth in claim 1].1 / 1 resumo “composto ou um sal farmaceuticamente aceitã�vel do mesmo, composiã‡ãƒo farmacãšutica, inibidor da xantina oxidase, e, agente terapãšutico ou profilã�tico para uma doenã‡aâ€� sã£o fornecidos um composto expressado pela fã³rmula (i) ou um sal farmacologicamente permissã­vel do mesmo, assim como um droga ou composiã§ã£o de droga que contenham este composto como um ingrediente ativo, tendo um efeito inibidor da xantina oxidase que ã© muito ãºtil para tratar ou prevenir doenã§as que sã£o contribuã­das pela xantina oxidase, tais como gota, hiperuricemia, sã­ndrome da lise de tumor, cã¡lculos do trato urinã¡rio, hipertensã£o, dislipidemia, diabetes, doenã§a cardiovascular tal como insuficiãªncia cardã­aca e esclerose arterial, doenã§a renal tal como opacidade quase diabã©tica e similares, doenã§a respiratã³ria tal como doenã§a pulmonar obstrutiva crã´nica e similares, doenã§as autoimunes tais como doenã§a 1 inflamatã³ria do intestino e similares. [na fã³rmula, a, x, y, z, r e r tãªm os s

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中国工程科技知识中心

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http://www.ckcest.cn/home/