THE BRIGHAM AND WOMEN'S HOSPITAL, INC.;MASSACHUSETTS INSTITUTE OF TECHNOLOGY
发明人:
TRAVERSO, CARLO GIOVANNI,ABRAMSON, ALEX G.,CAFFAREL SALVADOR, ESTER,ROXHED, NICLAS,KHANG, MINSOO,BENSEL, TAYLOR,LANGER, ROBERT S.
申请号：
CA3063713
公开号：
CA3063713A1
申请日:
2018.05.17
申请国别(地区):
CA
年份:
2018
代理人:
摘要：
Components with relatively high loading of active pharmaceutical ingredients are generally provided. In some embodiments, the component (e.g., a tissue interfacing component) comprises a solid therapeutic agent and a supporting material such that the solid therapeutic agent is present in the component in an amount of greater than or equal to 10 wt% versus the total weight of the tissue interfacing component. Such tissue-interfacing components may be useful for delivery of API doses e.g., to a subject. Advantageously, in some embodiments, the reduction of volume required to deliver the required API dose as compared to a liquid formulation permits the creation of solid needle delivery systems for a wide variety of drugs in a variety of places/tissues (e.g., tongue, Gl mucosal tissue, skin) and/or reduces and/or eliminates the application of an external force in order to inject a drug solution through the small opening in the needle. In some cases, a physiologically relevant dose may be present in a single tissue interfacing component.
