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JAK2 AND ALK2 INHIBITORS AND METHODS FOR THEIR USE
专利权人:
发明人:
MOLLARD ALEXIS,WARNER STEVEN L,FLYNN GARY A,VANKAYALAPATI HARIPRASAD,BEARSS DAVID J
申请号:
IN9099/DELNP/2015
公开号:
IN2015DN09099A
申请日:
2015.10.03
申请国别(地区):
IN
年份:
2016
代理人:
摘要:
Compounds having activity as inhibitors of ALK2 kinase and/or JAK2 kinase are disclosed. The compounds have the following structure (I): [FORMULASHOULD BE INSERTED HERE] including stereoisomers,tautomers, pharmaceutically acceptable salts and prodrugs thereof, wherein R1, R2, R3, R4, R5, R6, R7, R8, X, z and A are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.
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