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シュウ酸誘導体およびその生理的冷却作用成分としての使用
专利权人:
シムライズ アーゲー
发明人:
ホルシュト ズルブルク,ヤン ローフト,ハイコ エルトリンク,トビアス フェージンク
申请号:
JP2008238643
公开号:
JP5637654B2
申请日:
2008.08.20
申请国别(地区):
JP
年份:
2014
代理人:
摘要:
A composition comprises at least one oxalic acid derivative and/or mixture of oxalic acid derivatives. A composition comprises at least one oxalic acid derivative of formula B-O-C(O)-C(O)-X (I) excluding azetidin-1-yl-oxo-acetic acid 2-isopropyl-5-methyl-cyclohexyl ester N-(4-phenyl-thiazol-2-yl)-oxalamic acid 2-isopropyl-5-methyl-cyclohexyl ester and [2-(5-nitro-furan-3-yl)-[1,3]oxazinan-3-yl]-oxo-acetic acid 2-isopropyl-5-methyl-cyclohexyl ester or at least one oxalic acid derivative of formula B-O-C(O)-C(O)-X a(II) and/or mixture of oxalic acid derivatives. B : hydrocarbon residue selected from 2-isopropyl-5-methyl-cyclohexyl, 2-isopropenyl-5-methyl-cyclohexyl, 2-isopropylidene-5-methyl-cyclohexyl, 5-isopropyl-2-methyl-cyclohexyl, 2-isopropyl-5-methyl-phenyl, 1-isopropyl-2-methyl-cyclohexyl, 1-isopropyl-cyclohexyl, 1-isopropyl-cycloheptyl, 1-isopropyl-2-methyl-cyclopentyl, 3-isopropyl-bicyclo[2.2.1]hept-5-en-2-yl, 1,3,3-trimethyl-bicyclo[2.2.1]hept-2-yl, 7,7-dimethyl-bicyclo[2.2.1]hept-2-yl, 3,3,5-trimethyl-cyclohexyl, 2,4-dimethyl-pentan-3-yl, 2,3,4-trimethyl-pentan-3-yl, 3,5-dimethyl-heptan-4-yl, 2,4-dimethyl-hexan-3-yl, or 2,3,4-trimethyl-hexan-3-yl X : NR 1R 2or SR 3 R 1-R 3H, or 1-12C organic residueor NR 1R 2ring X aNR 1 aR 2 aor SR 3 a R 1 a-R 3 a1-5C alkyl, 3-8C cycloalkyl, 2-4C alkenyl, 2-4C alkynyl, propynyl, 1-4C perfluoroalkyl, hydroxy, 1-8C alkoxy, 3-8C cycloalkoxy, 1-4C acyl, 1-4C alkoxycarbonyl, 1-4C acyloxy or 2-7C heteroalkyl. An independent claim is included for production of the compound (I) involving reacting mixed oxalic acid ester of formula B-O-C(O)-C(O)-OR a(III) or oxalic acid halide of formula B-O-C(O)-C(O)-Hal (IV), with an amine of formula HNR 1R 2, thiol formula HSR 3or their salts. R aalkyl residue Hal : halide. ACTIVITY : Antiinflammatory Antitussive Virucide. No biological data given. MECHANISM OF ACTION : None given.
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