The present invention provides for the use of a p75 receptor antagonist or its pharmaceutically acceptable salts for the preparation of a medicament for use in the treatment and/or prevention of overactive bladder.本發明提供一種p75受體拮抗劑或其醫藥可接受鹽於製造用在治療及/或預防膀胱過動症中之藥物上之用途。