The invention comprises an atherectomy probe for mechanically cutting core prostatic tissue to alleviate the condition of benign prostatic hyperplasia (BPH) or for use in orthopedic procedures. The blade shapes and lengths are adaptable but in a preferred embodiment the device includes an end-cutting bur tip. The cutting motion may be one of: guillotine (incising between two parallel edges), radial reciprocating (changing radial directions and cuts between two horizontal edges), circular (continuously radial in one direction), and end-cutting, etc. The power source used to drive the blade may be one of: pneumatic, hydraulic, manual mechanical, electrical, solar, etc. The probe also includes several channels that may be used for providing live aspiration and removal of severed tissue and fluids, as well as insufflation of gases and optionally, pharmaceuticals and/or a secondary therapy. The instrument is designed for use in open, endoscopic, and minimally invasive transurethral or transperineal surgical procedures.
