Howard, Philip Wilson,Van Berkel, Patricius Hendrikus Cornelis
申请号：
NZ70749013
公开号：
NZ707490A
申请日:
2013.10.11
申请国别(地区):
NZ
年份:
2018
代理人:
摘要：
The present invention relates to pyrrolobenzodiazepines (PBDs) having a labile N10 protecting group in the form of a linker to an antibody, wherein the antibody is an antibody that binds to CD22, the antibody comprising a VH domain paired with a VL domain, the VH and VL domains having sequences of SEQ ID NO. 1 paired with SEQ ID NO. 2. The drug loading (p) of drugs (D) to antibody (Ab) is an integer from 1 to 8. The present invention is suitable for use in providing a PBD compound to a preferred site in a subject. The conjugate allows the release of an active PBD compound that does not retain any part of the linker.
