KUO, Tracy Chia-Chien,CHAPARRO RIGGERS, Javier Fernando,CHEN, Wei,CHEN, Amy Shaw-Ru,PASCUA, Edward Derrick,VAN BLARCOM, Thomas John,BOUSTANY, Leila Marie,HO, Weihsien,YEUNG, Yik Andy,STROP, Pavel,RAJP
申请号：
PE0021042017
公开号：
PE00462018A1
申请日:
2016.03.30
申请国别(地区):
PE
年份:
2018
代理人:
摘要：
Refers to isolated an Antibody or an antigen, which binds to a fragment of the same, which specifically binds a b-cell maturation antigen (BCMA) Antibody, which comprises: (a).A variable region of heavy chain (VH) which includes: (i) the complementarity Determining Region (CDR1) comprising the Amino Acid Sequence SEQ ID no: 301, 302, SEQ ID no:Or SEC ID no: 303 (ii) CDR2 VH comprising the sequence SEQ ID no: 305 or SEQ ID no: 306 and (iii) a CDr3 VH comprising the sequence SEQ ID no: 307, 308 (SEQ ID no: B.) a light chain variable region (VL) comprising: (i) a CDR1 VL comprising the Amino Acid Sequence SEQ ID no: 309, (ii) a VL CDR2 comprising the sequence SEQ ID no: 310And (iii) a CDr3 VL comprising the Amino Acid Sequence SEQ ID no: 311, or SEQ ID no: 312.Even More heteromultimericos relates to Antibodies that Bind specifically to a cluster of Differentiation 3 (CD3) and a tumor Cell antigen (e.g.Biespecificos Antibodies that specifically bind to CD3 and BCMA). It also relates to a Pharmaceutical composition, an isolated polynucleotide, a Vector and a host cell.The bioespecifico Antibody is useful as a Medicament for the treatment of cancer like Multiple Myeloma, malignant plasma Cell neoplasm, among others.Se refiere a un anticuerpo aislado, o un antigeno que se une a un fragmento del mismo, que se une especificamente un antigeno de maduracion de celulas B (BCMA), en donde el anticuerpo comprende: (a.) una region variable de cadena pesada (VH) que comprende: (i) una region determinante de la complementariedad uno (CDR1) que comprende la secuencia de aminoacidos SEQ ID NO: 301, SEQ ID NO: 302,o SEC ID NO: 303 (ii) una CDR2 de VH que comprende la secuencia SEQ ID NO:305,o SEQ ID NO: 306 y (iii) una CDR3 de VH que comprende la secuencia SEQ ID NO: 307, SEQ ID NO: 308 (b.) una region variable de cadena ligera (VL) que comprende: (i) una CDR1 de VL que comprende la secuencia de aminoacidos SEQ ID NO: 309, (ii) una CDR2 de VL que comprende la secuencia SEQ ID NO: 310,
