PROBLEM TO BE SOLVED: To provide a novel arteriosclerosis drug that controls infiltration of macrophage into an artery and is thereby capable of controlling thickening and fibrosis of aortic tunica media.SOLUTION: The arteriosclerosis drug includes nitroso nifedipine and a nitroso nifedipine derivative such as nitroso-nisoldipine, nitroso-nimodipine, nitroso-nicardipine and nitroso-nitrendipine nitroso nifedipine as active ingredients. The drug can control infiltration of macrophage into an artery that has a large influence on the progress of arteriosclerosis to control thickening and fibrosis of smooth muscle media of an arterial vessel. Thus, the drug improves various symptoms of arteriosclerosis and is useful as prevention or a drug of a disease related to arteriosclerosis.【課題】新規動脈硬化症治療剤の提供。【解決手段】ニトロソニフェジピン、および、ニトロソ－ニソルジピン、ニトロソ－ニモジピン、ニトロソ－ニカルジピン、ニトロソ－ニトレンジピンニトロソニフェジピン等のニトロソニフェジピン誘導体を有効成分とする動脈硬化症治療剤。動脈硬化の進展に大きな影響を与えるマクロファージの動脈内への浸潤を抑制でき、動脈血管の平滑筋中膜の肥厚と線維化を抑制。これにより、動脈硬化の諸症状を改善し、動脈硬化に関連する疾患の予防又は治療剤として有用。【選択図】なし
