The disclosure provides improved methods for treating or preventing a class of undesired health events including multiple related maladies, such as a disease, condition, or syndrome or the like. The improvement results from optimization of energy metabolism by administering a therapeutically effective compound selected to a) modulate mitochondrial activity to correct for deficiencies resulting from the disease, b) to boost cell energy metabolism thereby improving the original methods efficacy, and/or c) to correct for metabolic disruptions resulting from therapies or medicaments used in the method to be improved. A combination therapy may be designed based on a disease, a group and/or an individual, said combination comprising one or more energy optimization booster combined with a medicament used in an original method is an exemplary embodiment. In some circumstances optimization may involve boosting energy metabolism throughout an organism or in selected cells, tissues or subcellular structures in some circumstances optimization may involve diminishing energy metabolism throughout an organism or in selected tissues, cells or subcellular structures. In several circumstances diminishing energy metabolism in selected cells to zero or near zero may, by essentially destroying or eliminating mitochondrial functionality of these cells to impair or destroy adverse functionality of these cells or subcellular activity, be optimal for the organism. Biochemicals, including biotherapeutics, may be delivered by any effective method or device, including, but not limited to: injection, oral dosing, nanodelivery, suppository, patches, eye drops, nasal spray, ointment, cream, synthetic gene, conjugated molecule, catheter, timed or controlled release capsule or pill, subdermal implants, diet, etc.
