Antibodies that bind to the receptors of the blood-brain Barrier (BBB - R) and Methods of Use thereof.Claim 1: a compound method of Transport across the blood-brain Barrier which comprises exposing an Antibody that binds to a receptor with low Affinity of the blood-brain Barrier (BBB R) coupled to a compound to the blood-brain Barrier, so that the anticuer Coupled to this po carries the compound through the blood-brain Barrier.The Method of claim 20: According to any one of claims 1 to 6, The BBB R is selected from the group consisting of transferrin receptor (TFR) receptor, Insulin Receptor, insulin-like Growth Factor (IGF Receptor Related Protein), the recep Tor of low density lipoprotein (lrp8), 8Protein related to the low density lipoprotein receptor 1 (LRP1), and type of growth factor epidermal growth factor binding to heparin (hb-egf).Claim 26: The Method according to claim 25, which comprises a First multispecific Antibody with the Antigen binding site that binds to BBB - R and a Second binding site with the Antigen that binds to an Antigen in brain.The Method of claim 27: 26, according to the claim, where the Brain Antigen is selected from the group consisting of: (1) B - secretase BACE1), AB, epidermal growth factor receptor (EGFR), Human epidermal growth factor receptor 2 (HER2), Tau, apolipopro The E4 (apoE4), - synuclein, CD20, Huntingtin, Prion Protein (PRP)Leucine Rich Repeat kinase 2 (Parkin, LRRK2), Presenilin 1, Presenilin 2, G secretase, Death receptor 6 (DR6), amyloid precursor protein (APP), P75 neurotrophin receptor (p75NTR), and caspase 6.Anticuerpos que se unen a los receptores de la barrera hematoencefálica (BBB-R) y los métodos de usarlos mismos.Reivindicación 1: Un método de transporte de un compuesto a través de la barrera hematoencefálica que comprende exponer un anticuerpo que se une con afinidad baja a un receptor de la barrera hematoencefálica (BBB-R) acoplado a un compuesto a la barrera hematoencefálica de modo que el anticuerpo trans
