Systems, methods and devices for performing water aided endoscopy (WAE) are provided herein. The systems include a plurality of devices designed to create a sealed environment within the body cavity, including a multi-functional plug, valves, balloons and pumps. The systems also provide specialized tools configured for operation within a liquid environment which are designed to interface with the multi-functional seal for insertion into the body cavity while maintaining the seal, including an adjustable constant shape snare. Additional features of the systems and methods include specialized fluids for increasing visibility with the body cavity, dyes and other solutions for image-enhancement and diagnostics, and software for increasing the clarity of the image in real-time.
