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APPLICATION OF AROMATASE INHIBITOR FOR TREATMENT OF HYPOGONADISM AND RELATED DISEASES
专利权人:
НОВАРТИС АГ
发明人:
ТЭЙЛОР Энн,КЛИКСТЕЙН Ллойд Б.
申请号:
RU2014113334
公开号:
RU2014113334A
申请日:
2012.09.06
申请国别(地区):
RU
年份:
2015
代理人:
摘要:
1. A method of treating hypogonadism in a male patient with serum total testosterone levels below 400 ng / dl and in need of increasing testosterone levels, comprising administering to said patient an effective amount of compound 4.4 '- [fluoro- (1H-1,2,4 -triazol-1-yl) methylene] bisbenzonitrile, where the effective amount of the compound is from about 0.0005 mg to about 2.0 mg per dose, and where the compound is administered in accordance with a dosage regimen characterized by a dosage frequency selected from approximately one once a day, up to about once every 60 days. The method of claim 1, wherein the male patient is overweight or obese. The method of claim 1 or 2, wherein the method is used to treat hypogonadotropic hypogonadism. The method of claim 1, wherein the male patient has a total serum testosterone level below 300 ng / dl. The method of claim 1, wherein the level of testosterone is increased by at least 10% compared with the level of testosterone prior to administration of the compound, preferably where the level of testosterone is normalized. The method of claim 1, wherein the patient needs to prevent or treat one or more disorders selected from metabolic syndrome, type II diabetes, obesity, cardiovascular disease, insulin resistance, lack of glucose tolerance, dyslipidemia, decreased libido, decreased spontaneous erections, erectile dysfunction, decreased fertility, loss of hair, reduced need for shaving, loss of strength, fatigue, poor health, depression, mood changes, low mineral bone density, increased1. Способ лечения гипогонадизма у пациента мужского пола с уровнями общего тестостерона в сыворотке ниже 400 нг/дл и нуждающегося в повышении уровней тестостерона, включающий введение указанному пациенту эффективного количества соединения 4,4'-[фтор-(1H-1,2,4-триазол-1-ил)метилен]бисбензонитрила, где эффективное количество соединения составляет приблизительно от 0,0005 мг до приблизительно 2,0 мг в одной дозе, и где соединение вводят в соответствии
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