The present disclosure provides for methods of improving the efficacy of T cells. In an aspect, the disclosure further provides for methods of enhancing the persistence of T cells for adoptive cell transfer or therapy (ACT). Cytokine sensitivity assays (CSA) and associated methodology capable of predicting the persistence of adoptively infused T Cells are further provided for by way of the instant disclosure. The disclosure also provides for methods of treating cancer in a subject in need thereof as well as T cells populations produced by methods described herein.本揭示提出了改善 T 細胞療效的方法。在一態樣中，本揭示進一步提出了增強用於過繼細胞轉移或治療 (ACT) 的 T 細胞的持久性的方法。透過本揭示進一步提出了能夠預測過繼輸注 T 細胞持久性的細胞因子敏感性測定 (CSA) 和相關方法。本揭示還提出了有此需要受試者的癌症治療方法以及透過本文描述的方法產生的 T 細胞群。
